Research reveals no relevant animal data regarding the use of garlic as an antithrombotic agent. Time-release garlic powder capsules are also being used in clinical studies.67, One resource suggests the following doses: 2 to 5 g of fresh raw garlic; 0.4 to 1.2 g of dried garlic powder; 2 to 5 mg garlic oil; 300 to 1,000 mg of garlic extract (as solid material); and 2,400 mg/day aged garlic extract (liquid).2, 110, Clinical trials have evaluated 180 mg of allicin daily for prevention for the common cold,11 and at least 5.5 g of raw garlic for the prevention of prostate cancer.49, Administer with food to prevent GI adverse reactions.2, Garlic may be used safely in pregnancy and lactation.2 In 8 breast-feeding mothers, garlic odor in breast milk peaked after 2 hours of ingestion and decreased thereafter. The proposed mechanism for garlic oil inhibition of platelet function is via methylallyltrisulfide interference with thromboxane synthesis. Some studies used aged garlic or heat treated garlic and this can lower the effectiveness in reducing blood pressure. The weight loss effects are either small or nonexistent in otherwise normal conditions. The lipid indices that showed significant improvement with garlic supplementation were HDL cholesterol (P = 0.003) and plasma triacylglycerols (P = 0.021). Garlic supplementation can also be done through food alone, though side-effects will include strong garlic-scented breath. This results in the following maximum dosages: Become an Examine.com member to get access to the latest research. turmeric, echinacea, milk thistle, creatine, saw palmetto. No hard outcomes data from the study period were reported.96, In South Korean patients with mild hepatic dysfunction and an elevated gamma-glutamyl transpeptidase (GGT), administration of fermented garlic extract (1.5 g/day) for 12 weeks provided a significant decrease in GGT compared to controls but only in the subgroup of patients who consumed alcohol in the 6 weeks prior to the study (P=0.015). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 2013;6:49-56. Only 1 trial out of 5 met quality standards (adequate randomization and concealment), finding that 180 mg of allicin daily for 12 weeks resulted in a lower incidence of colds versus placebo.10 Limited clinical studies have evaluated garlic in cystic fibrosis and have found no effect on Pseudomonas aeruginosa infection or on pulmonary function.8, 10, 11, Antioxidant properties have been described, but aside from a role in cancer and hepatoprotection against chemical insult, clinical applications are lacking.25, 63, 64, 65, 66. Quality of life in cancer patients is unaffected despite an increase in NK cell activity, thought to be indicative of a therapeutic effect of supplementation. While there are signficant modifications in the subpopulations of white blood cells (ie. Consider therapy modification.71, 72, 73, 74, Hypoglycemic agents: Herbs (hypoglycemic properties) may enhance the hypoglycemic effect of hypoglycemic-associated agents. Garlic may be used safely in pregnancy and breast-feeding at usual doses. C-reactive protein levels compared with baseline were reduced in the treatment group, and higher than baseline in the placebo group. Consider therapy modification.71, 72, 73, 74, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. While heterogeneity of studies was low, the definition of "high intake" varied greatly among studies, ranging from every meal or every day to a few times a month.105 A Chinese case-control study found that consumption of raw garlic reduced the risk for lung cancer.95, A relationship between an increase in allium food consumption (onion and garlic) may exist with a decreased incidence of benign prostatic hyperplasia.62, A Cochrane systematic review of data found only one 12-week study (n = 146) that showed significantly fewer cold episodes and days of illness with garlic compared with placebo but similar recovery times between the 2 groups. Current drug therapy with omeprazole may facilitate sensitization to food allergens.111 Cross-sensitivity to other members of the Liliaceae family, Amaryllis family (Amaryllidaceae), and asparagus may be observed.80, 82, 83, 84, 85, 111 A case of black-garlic-induced pneumonia was documented in a 77-year-old female who presented with dyspnea and coughing.

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