It is the first solution offered for emergency decontamination of tissues brought into contact with a chemical product. It is by the combination of these properties that Diphoterine® solution is uniquely able to achieve the three elements demanded for effective emergency first aid of a chemical splash: Tests have shown Diphoterine® to be more effective than water: Diphoterine®  solution has been used for 25 years  in industry throughout Europe and is registered as a Class IIa Medical Device, Diphoterine® solution conforms with the European Standards for Emergency Showers -  EN15154: Parts 3 and 4. It is a polyvalent, slightly hypertonic, amphoteric, water-soluble molecule which binds acids, bases, oxidizing agents, reducing agents, solvents, irritants, alkylating agents, and radionuclides. Diphoterine® solution is an emergency rinsing solution for splashes of chemical products. Diphoterine® solution is an emergency rinsing solution for splashes of chemical products. A different solution, Hexafluorine, is required to deal with hydrofluoric acid contamination. The Diphoterine® molecule is polyvalent and can effectively prevent the corrosive or irritant action of acids, alkalis, oxidising agents, reducing agents, chelating agents and solvents. This makes it possible to limit the extent of the burns and lesions caused. Rinsing with water however has a limited action and offers a number of disadvantages.

Zack-Williams, S. D., Ahmad, Z., & Moiemen, N. S. (2015).

While water is often thought of as the preferred treatment for chemical contact on skin and eyes, Diphoterine® solution is proven to deliver better outcomes compared to passive water washing. First aid procedures for chemical injuries often recommend rinsing the affected skin with water. This additional physical effect is minor in relation to mechanical rinsing of the chemical product. Corrosive and irritant chemical products react with the biological components of the skin or eye. Diphoterine® solution is a class IIa medical device according to Directive 93/42 EEC.

Why rinse and decontaminate a chemical burn injury? Furthermore, it allows the vast majority of chemical products to be rinsed off with the same efficacy. The chemical products quickly penetrate into the skin or the eye, creating deep-lying lesions.

In order to decontaminate effectively, the contact time and the reactions between the aggressive chemical product and the biological tissue must be restricted. Diphoterine® solution is liquid: it therefore allows performance of effective mechanical rinsing of the chemical product on the surface of the skin or the eye.

For instance, an acid that penetrates into the skin will reduce the pH of the skin that it contaminates. Rinsing with water encourages penetration of the chemical product inside the tissues. Rinsing with water does not have any effect on the chemical product that has already penetrated into the tissues.

Studies comparing initial TMAH decontamination with Diphoterine versus tap water were performed: an in vitro pH titration study and an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) in vitro cytotoxicity cell viability assay. The intervention period for rinsing with water is very short in order to obtain an optimum result.

Its rapid use in case of contact between the skin or eye and a chemical product is intended to quickly eliminate the residual chemical product on the skin or in the eye.

Finally, rinsing with water makes it possible to: Experimental studies showed that rinsing with water was not optimum and that it was possible to improve emergency management of a chemical burn, particularly for corrosive and irritant products. Chemical Name: Diphoterine: CAS Number: 155575-59-0: Product Number: AGN-PC-0Q6X0M Synonyms: MDL No: Molecular Formula: Molecular Weight: This makes it possible to limit penetration of the chemical product inside the tissues.

Diphoterine® is a washing solution designed for eye and skin chemical splashes. Diphoterine® solution is a hypertonic solution: it has an osmotic pressure greater than that of the skin and the eye.

The presence of phosphates in a solution prevents its use on certain products (e.g. Removal of chemical from the surface of the tissue.

Owing to its physical and chemical properties, Diphoterine® solution allows rinsing to be performed more effectively than with water in case of splashing of chemical product. [3] Moody, R. P.; Maibach, H. I.; Skin decontamination: Importance of the Wash-in effect, Food and Chem. A hexafluoride is a chemical compound with the general formula QX n F 6, QX n F 6 m−, or QX n F 6 m+.Many molecules fit this formula. [1] Diphoterine® solution can be used in complete safety. Limit the corrosive or irritant potential of the chemical product in order to prevent development of lesions.

An important hexafluoride is hexafluorosilicic acid (H 2 SiF 6), which is a byproduct of the mining of phosphate rock.In the nuclear industry, uranium hexafluoride (UF 6) is an important intermediate in the purification of this element. Hence, a portion of the water used for rinsing will penetrate inside the tissue, taking a small amount of chemical product with it. The less the chemical product is concentrated, the less it is aggressive to biological tissues. Diphoterine® is an eye/skin chemical splash decontamination solution produced by Laboratoire Prévor in France. Its physical and chemical properties allow performance of rinsing if chemicals are splashed on humans. The spray is sterile and has a shelf life of two years. This recommendation for decontamination of chemical splashes is historical and still remains widespread. This is because hydrofluoric acid is poisonous as well as corrosive.

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