The melting point is the temperature in which aspirin will go from a solid to a liquid. High or Appearance: white powder. endstream endobj 19 0 obj<> endobj 21 0 obj<> endobj 22 0 obj<>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageC/ImageI]/ExtGState<>>> endobj 23 0 obj<> endobj 24 0 obj<> endobj 25 0 obj<> endobj 26 0 obj<> endobj 27 0 obj[/ICCBased 41 0 R] endobj 28 0 obj[/Indexed 27 0 R 255 42 0 R] endobj 29 0 obj<> endobj 30 0 obj<> endobj 31 0 obj<> endobj 32 0 obj<> endobj 33 0 obj<>stream Aspirin has a boiling point of 140 degrees Celsius, which is 284 degrees Fahrenheit, and it has a melting point of 135 degrees Celsius, which is 275 degrees Fahrenheit. 0000003291 00000 n repeated exposure may cause headache, dizziness, depression and are teratogenic in. In the second half of the nineteenth century, other chemists established the chemical structure and came up with more efficient methods to make it. 1999 Jun;26(6):1366-73. irritability. Service | 0 swallowed. It is useful in the treatment of those parts of the heart which had an attack. Chronic: [aspirin] [Note: Develops the vinegar-like odor of acetic acid on contact with moisture.]. May cause liver and Science. It is weakly acidic in nature. The Preparation of Aspirin, the Recrystallisation of Aspirin and the Melting Point Determination of Aspirin. 20 0 obj<>stream Kopp E, et al. Target Organs: Blood, respiratory system, eyes, Chondrocytes are isolated from articular cartilage of donors with no articular disease. There is no conclusive evidence that salicylates Int., 13, 1979, 71-79. umn class: Standard non-polar; Column type: Packed; Start T: 150 C; CAS no: 50782; Active phase: OV-1; Data type: Kovats RI; Authors: Berninger, H.; Moller, M.R., Retentionsindices zur gaschromatographischen Identifizierung von Arzneimitteln, Arch. 0000007819 00000 n J Rheumatol. Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound that inhibits Cox-1. Organic Compound; Ester; Drug; Food Toxin; Anticoagulant; Fibrinolytic Agent; Antipyretic; Anti-Inflammatory Agent, Non-Steroidal; Cyclooxygenase Inhibitor; Metabolite; Platelet Aggregation Inhibitor; Salicylate; Synthetic Compound, ORL-RAT LD50 200 mg kg-1 , SKN-RBT LD50 > 7940 mg kg-1 , ORL-MAM LD50 1750 mg kg-1 , ORL-MAN LD50 (estimated) 400 mg kg-1, P261-P280-P305+P351+P338-P304+P340-P405-P501a, WARNING: Irritates skin and eyes, harmful if swallowed, Eye: Irrigate immediately Skin: Soap wash Breathing: Respiratory support Swallow: Medical attention immediately, inhalation, ingestion, skin and/or eye contact, Irritation eyes, skin, upper respiratory system; increased blood clotting time; nausea, vomiting; liver, kidney injury, Eyes, skin, respiratory system, blood, liver, kidneys, Solutions of alkali hydroxides or carbonates, strong oxidizers, moisture [Note: Slowly hydrolyzes in moist air to salicyclic & acetic acids. Edexcel Chemistry. is controversial. In this reaction, when salicylic acid reacts with acetic anhydride, the hydroxyl group of salicylic acid converts into an ester group. ;Target: Cox-1Aspirin (USAN), also known as acetylsalicylic acid , is a salicylate drug, often used as ananalgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. C6H4(OH)COOH + (CH3CO)2O CH3COOC6H4COOH + CH3COOH. Aspirin is a general medication used for pain, fever, inflammation, heart attacks etc. It easily decomposes in the solution of ammonium acetate, carbonates, citrates or alkali metal hydroxides. Exhibits antiplatelet and antithrombotic activities. Eye: About Us | Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. Wu KK, et al. [2]. Aspirin is NSAID (Nonsteroidal anti-inflammatory drug) but it suppresses the normal functioning of platelets. Heat Stress Induces Extended Plateau of Hsp70 Accumulation--A Possible Cytoprotection Mechanism in Hepatic Cells. Metabolic pathways for phenacetin involve de-ethylation, N-deacetylation and ring hydroxylation. [3]. Core Practicals. 0000003929 00000 n By the reaction of salicylic acid and acetic anhydride in the presence of sulfuric acid/ phosphoric acid as catalyst. umn class: Standard non-polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Start T: 130 C; CAS no: 50782; Active phase: DB-1; Carrier gas: N2; Phase thickness: 1.5 um; Data type: Kovats RI; Authors: Japp, M.; Gill, R.; Osselton, M.D., Comparison of drug retention indices determined on packed, wide bore capillary and narrow bore capillary columns, J. Forensic Sci., 32(6), 1987, 1574-1586. umn class: Standard non-polar; Column length: 6 ft; Column type: Packed; CAS no: 50782; Active phase: OV-101; Carrier gas: N2; Substrate: Chromosorb W; Data type: Kovats RI; Authors: McLinden, V.J. [4]. Aspirin is available as a generic medication. Aspirin given shortly after a heart attack decreases the risk of death. This ends our coverage on the topic “Acetylsalicylic acid”. Science. It is weakly acidic in nature. As of 2015 the cost for a typical month of medication in the United States is less than US$25. Aspirin has different chemical features than any other molecules. The synthesis of aspirin is classified as an esterification reaction. Once it is a liquid, the boiling point is the temperature that the vapor pressure of the liquid is large enough that bubbles form inside the body of the liquid. Wu KK, et al. 0000009020 00000 n Blocks the production of prostaglandins and thromboxanes. Blanco FJ, et al. The wholesale cost in the developing world as of 2014 is 0.002 to 0.025 USD per dose. Exhibits antiplatelet and antithrombotic activities. It is commonly prescribed for because of its properties such as anti – inflammatory, anti – coagulatory, fever reducing and pain relieving. Old aspirin exposed to moisture often smells like acetic acid (vinegar). Articles of Aspirin are included as well. Whether or not acetaylsalicylic acid (aspirin) is a human teratogen CopyCopied, InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) When aspirin is heated in boiling water, it decomposes and gives off a vinegar smell. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. ]. ; Stenhouse, A.M., A chromatography system for drug identification, Forensic Sci. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Aspirin has a boiling point of 140 degrees Celsius, which is 284 degrees Fahrenheit, and it has a melting point of 135 degrees Celsius, which is 275 degrees Fahrenheit. Vedantu academic counsellor will be calling you shortly for your Online Counselling session. Its acid dissociation constant (pKa) is 3.5 at 25 °C (77 °F). Specific inflammatory conditions in which it is used include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, and inflammation. All the O atoms have lone pairs of electrons. 0000011689 00000 n Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound that inhibits Cox-1. Why is this test positive? Bayer named it Aspirin. 18 27 8.2 Required practical activities. Warning! 1994 Aug 12;265(5174):956-9. 0000003853 00000 n Chemical Properties of Aspirin – It Shows Following Chemical Properties, Dichloromethane Uses and Effects on Environment, Preparation of Standard Solution of Oxalic Acid, Potassium Dichromate - Formula, Properties & Uses, Classification of Elements and Periodicity in Properties, NCERT Solutions for Class 11 Chemistry Chapter 3, NCERT Solutions for Class 11 Chemistry Chapter 4, Electric Current and Its Effects NCERT Solutions - Class 7 Science, NCERT Solutions for Class 11 chemistry chapter 2 – Structure of Atom, NCERT Solutions for Class 7 Maths Chapter 6 The Triangle and its Properties, NCERT Solutions for Class 10 Science Chapter 13, NCERT Solutions for Class 11 Chemistry Chapter 4 Chemical Bonding and Molecular Structure In Hindi, Cell Structure and Functions NCERT Solutions - Class 8 Science, NCERT Solutions for Class 11 Chemistry Chapter 2 Structure of Atom In Hindi, NCERT Solutions for Class 11 Chemistry Chapter 3 Classification of Elements and Periodicity in Properties In Hindi, CBSE Class 7 Maths Chapter 6 - Triangle and Its Properties Formulas, CBSE Class 11 Physics Thermal Properties of Matter Formulas, CBSE Class 11 Physics Mechanical Properties of Solids Formulas, CBSE Class 11 Physics Mechanical Properties of Fluids Formulas, Class 11 Chemistry Revision Notes for Chapter 3 - Classification of Elements and Periodicity in Properties, Class 11 Chemistry Revision Notes for Chapter 4 - Chemical Bonding and Molecular Structure, Class 11 Chemistry Notes for Chapter 2 - Structure of Atom, Vedantu Have questions or comments? ; Target: Cox-1; Aspirin (USAN), also known as acetylsalicylic acid , is a salicylate drug, often used as ananalgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Kopp E, et al. 18 0 obj<> endobj Hygroscopic (absorbs moisture from the It can be explosive when mixed with air in its powdered form. When we tested the melting point, the range was 106-118. Acetylsalicylic acid has a molecular weight of 180.16 grams per mole, and it's density is 1.4 grams per centimeter cubed. Aspirin, an acetyl derivative of salicylic acid, is a white, crystallize, weakly acidic substance, with a melting point of 136oC and a boiling point of 140oC (Meyers, 2007). Bond Angles. Buying Leads | Ingestion may cause high blood pressure, labored Toxic if May be harmful if inhaled. Chemsrc provides Aspirin(CAS#:50-78-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is a white crystalline solid at room temperature. AT h: Use melting point apparatus. Soluble in ethanol, DMSO or water (3.3 mg/ml). Boiling Point: 136 °C (277 °F) Melting Point: 140 °C (284 °F) IUPAC Name. Toxicol., 37, 1977, 295-305. ass: Standard non-polar; Column type: Capillary; CAS no: 50782; Active phase: Polydimethyl siloxanes; Data type: Normal alkane RI; Authors: Schutz, H.; Wollrab A., The significance of the retention index in toxicologic analysis II, Pharmazie in unzerer Zeit, 17(4), 1988, 97-101. ass: Standard non-polar; Column type: Other; CAS no: 50782; Active phase: Methyl Silicone; Data type: Normal alkane RI; Authors: Ardrey, R.E. Semin Vasc Med. It is not recommended during pregnancy and to children with infections. 0000012762 00000 n We hope you enjoyed learning and were able to grasp the concepts. Acetylsalicylic Acid, also known by trade name Aspirin, is an acetyl derivative of salicylic acid that is a white, crystalline, weakly acidic substance, with melting point 137°C. Specific inflammatory conditions in which it is used include Kawasaki disease, pericarditis, and rheumatic fever. Toxic if swallowed. 2003 May;3(2):107-12. Causes respiratory tract irritation. Inhibitor of cyclooxygenase (COX)-1. Our actual yield was 2.87 grams. Salicylic acid, the main metabolite of aspirin, is an integral part of human and animal metabolism. It's soluble in water. 3g of aspirin can dissolve in 1 liter of water. Displays anticancer effects in some solid tumors. 1999 Jun;26(6):1366-73. 116 , 2365-74, (2015). The theoretical yield was 2.9 g, so the percent yield was 98.96%. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc. 0000000836 00000 n Displays anticancer effects in some solid tumors. By doing so, you will be able to access free PDFs of NCERT Solutions as well as Revision notes, Mock Tests and much more. Aspirin is less effective in inhibiting COX-2 activity.

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