J., 9(2), 1976, 69-74. class: Semi-standard non-polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Description: 40C(3min)=> 2C/min=>180C=>10C/min=>250C(5min); CAS no: 69727; Active phase: HP-5MS; Carrier gas: He; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Alissandrakis, E.; Kibaris, A.C.; Tarantilis, P.A. In contrast, when exogenous arachidonic acid is increased to 30 μM, Salicylic acid is a very weak inhibitor of COX-2 activity with an IC50 of >100 μg/mL. Nixon M, et al. [20], Salicylic acid has the formula C6H4(OH)COOH, where the OH group is ortho to the carboxyl group. A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. ; Moffat, A.C., Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase, J. Chemicals for Science Education. NIST Mass Spectrometry Data Center., 2011. http://www.medchemexpress.com/milnacipran-hydrochloride.html, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16914, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, 211 deg C / 20 mm (372.9924 °C / 760 mmHg), 211 °C / 20 mm Hg (372.9924 °C / 760 mmHg), 211 °C / 20 mmHg (372.9924 °C / 760 mmHg), 211 C / 20 mmHg (372.9924 °C / 760 mmHg) +Add Attachment Formula Weight: 138.12. Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. Moreover, this compound has a hydroxyl group located ortho to the carboxyl group. Further, it is an odourless compound with a melting point 158.6 °C and a boiling point 200 °C. Salicylic acid occurs in plants as free salicylic acid and its carboxylated esters and phenolic glycosides. Density (g/mL): 1.443. Chemsrc provides Salicylic acid(CAS#:69-72-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. [25] This remedy is mentioned in texts from ancient Egypt, Sumer and Assyria. Food Agric., 85, 2005, 1444-1452. ass: Standard non-polar; Column length: 3.05 m; Column type: Packed; Heat rate: 10 K/min; Start T: 40 C; End T: 250 C; End time: 60 min; Start time: 4 min; CAS no: 69727; Active phase: SE-30; Carrier gas: He; Substrate: Supelcoport and Chromosorb; Data type: Linear RI; Authors: Peng, C.T. A colorless, crystalline organic carboxylic acid. Tax rebate rate:9.0%. ; Tsypysheva, L.G. Chemsrc provides Salicylic acid(CAS#:69-72-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is poorly soluble in water (2 g/L at 20 °C).[21]. Acidification of the product with sulfuric acid gives salicylic acid: It can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid)[22] or methyl salicylate (oil of wintergreen) with a strong acid or base. Salicylic acid. In mesenteric adipose of C57Bl/6 DIO mice, Salicylic acid also reduces 11β-HSD1 enzyme activity[2]. In Arabidopsis thaliana it can be synthesized via a phenylalanine-independent pathway. 1997 Jun;51(6):907-12. Salicylic acid is biosynthesized from the amino acid phenylalanine. Diet-induced obese C57Bl/6 mice (C57Bl/6 DIO) are given 10 weeks of high-fat diet (58% fat, 12% sucrose) before treatment. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Soc. The salts and esters of salicylic acid are known as salicylates. ; Perrigo, B., A practical gas chromatographic screening procedure for toxicological analysis, Can. It is derived from the metabolism of salicin. ; Peel, H.W., The use of retention indices and temperature-programmed gas chromatography in analytical toxicology, J. Chromatogr. ; Yang, Z.C., Prediction of Retention Indexes I. Structure-Retention Index Relationship on Apolar Columns, J. Boiling Point: 211 deg C @ 20 mmHg Freezing/Melting Point:158 - 160 deg C Decomposition Temperature:Not available. Because instead of forming a hydroxyl group in salicylic acid, acetylsalicylic acid forms an ether of acetate. ; Suleimamova, R.A.; Naimushin, A.I. ; Hua, R.L. It is easily prepared on a clean surface by spraying a saturated solution of the salt in methanol followed by evaporation. [1]. The ability of Salicylic acid to directly inhibit COX-2 activity in A549 cells is tested after a 30-min exposure period, followed by the addition of different concentrations of exogenous arachidonic acid (1, 10, and 30 μM). Find chemicals information Salicylic acid at guidechem, professional and easy to use. Salicylic acid degrades to phenol and carbon dioxide at 200 - 230°C:[23], Hippocrates, Galen, Pliny the Elder and others knew that willow bark could ease pain and reduce fevers. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Anal. Sci., 19, 1981, 219-226. ass: Semi-standard non-polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Start T: 60 C; End T: 270 C; CAS no: 69727; Active phase: VF-5MS; Carrier gas: He; Phase thickness: 0.25 um; Data type: Linear RI; Authors: Todua, N.G., Retention Data. check more Salicylic acid price, Home | [10][11], Similar to other hydroxy acids, salicylic acid is a key ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis and warts.[12]. Visit BYJU'S to understand the properties, structure and uses of Salicylic Acid (C7H6O3) explained by India's best teachers. Physical Properties: Melting Point : 158-161 ºC. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. salicyloyl-CoA + H2O -> salicylate + coenzyme A + H+. Khim., 43, 1988, 143-146. ass: Standard non-polar; Column diameter: 0.25 mm; Column length: 15 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 130 C; End T: 290 C; End time: 10 min; Start time: 1 min; CAS no: 69727; Active phase: DB-1; Carrier gas: He; Phase thickness: 0.25 um; Data type: Normal alkane RI; Authors: Sharp, M.E., A rapid screening procedure for acidic and neutral drugs in blood by high resolution gas chromatography, J. Anal. Different concentrations of Salicylic acid are added to the plate, followed by the addition of 10 units of enzyme (180 μL). Human purified COX-2 are and the cofactors Glutathione (5 mM), Adrenaline (5 mM), and Hematin (1 μM) are dissolved in 50 mM Tris buffer (pH 7.5). Product Classification | [10] As such, it is used to treat warts, psoriasis, acne, ringworm, dandruff, and ichthyosis. Toxicol., 37, 1977, 295-305. ass: Standard non-polar; Column diameter: 0.2 mm; Column length: 20 m; Column type: Capillary; Heat rate: 4 K/min; Start T: 100 C; End T: 230 C; CAS no: 69727; Active phase: SE-30; Data type: Normal alkane RI; Authors: Shakirov, L.G. Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The username will be used as the login user name and retrieve the password, Copyright 2017 © ChemicalBook. Mol Pharmacol. [36][37], Some people with sensitivity to dietary salicylates may have symptoms of allergic reaction, such as bronchial asthma, rhinitis, gastrointestinal disorders, or diarrhea, and so may need to adopt a low-salicylate diet. [42], InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10), InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10), Except where otherwise noted, data are given for materials in their. The plates are incubated at 37° for 30 min before Arachidonic acid (10 nM to 30 μM) is added for a further 15 min. Freezing Point (°C): 158-160. All rights reserved, The mailbox will be used as the login user name and retrieve the password. dust mask type N95 (US);Eyeshields;Gloves, 2918211000. Salicylic acid (from Latin salix, willow tree) is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid (BHA). Organic Compound; Ester; Drug; Food Toxin; Plant Toxin; Anti-Infective Agent; Antifungal Agent; Metabolite; Keratolytic Agent; Household Toxin; Natural Compound; Synthetic Compound, ORL-RAT LD50 891 mg kg-1, ORL-MUS LD50 480 mg kg-1, Harmful/Irritant/Corrosive/Light Sensitive, Harmful/Irritant/Corrosive/Light Sensitive/dangerous for environment, P261-P280-P305+P351+P338-P304+P340-P405-P501a, WARNING: Causes GI injury, skin and eye irritation. Chromatogr., 436, 1988, 137-172. ass: Standard non-polar; Column length: 1.8 m; Column type: Packed; Heat rate: 8 K/min; Start T: 130 C; End T: 290 C; End time: 8 min; Start time: 2 min; CAS no: 69727; Active phase: SE-30; Carrier gas: N2; Substrate: Chromosorb W; Data type: Linear RI; Authors: Perrigo, B.J. [36], Salicylic acid is a phenolic phytohormone and is found in plants with roles in plant growth and development, photosynthesis, transpiration, ion uptake and transport.

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