One popular medication, called pravastatin, can be an effective option, but there are potential side effects to bear in mind. Accessed Jan. 25, 2019. However, researchers have found a "nocebo" effect when it comes to perceived muscle pain and statins. https://www.uptodate.com/contents/search. High cholesterol treatment: Does cinnamon lower cholesterol? . Some drugs that may interact with statins and increase your risk of side effects include: There are many drugs that may interact with statins, so be sure your doctor is aware of all the medicines you take when being prescribed with statins. Some people who take statins might experience an increase in blood sugar, which, over time, can lead to type 2 diabetes, according to the Mayo Clinic. Read more: The Truth About How Your Diet Affects Your Cholesterol. Statin-induced muscle syndromes. 2018;39:2526. Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images In: Ferri's Clinical Advisor 2019. Sometimes, taking a combination of cholesterol drugs can provide the same result with lower doses of statins. These side effects reverse once you stop taking the medication. Privacy Policy Rarely, if the increase is severe, you may need to try a different statin. Accessed Jan. 24, 2019. You wouldn't need any additional liver enzyme tests unless you begin to have signs or symptoms of trouble with your liver. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins. While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage. 2019;26:e000. A single copy of these materials may be reprinted for noncommercial personal use only. This causes your liver to remove cholesterol from your blood. She has a master’s degree in journalism from Columbia University. There is limited evidence to prove a cause-effect relationship, but talk to your doctor if you experience memory loss or confusion while taking statins. Adverse effects of statin therapy: Perception vs. the evidence — focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Indeed, as the Food and Drugs Administration points out, the drug itself is not associated with any significant changes in weight, based on clinical trial data cited on the pravastatin label. Accessed Jan. 29, 2019. Try coenzyme Q10 supplements. Because of this, be sure your doctor is aware of all drugs you take, including any that have been prescribed by other physicians, if pravastatin is being considered. All rights reserved. One of the most common complaints of people taking statins is muscle pain. She has written for the American Society of Clinical Oncology (ASCO) Daily News, SurvivorNet and Women’s Health Magazine. Cholesterol ratio or non-HDL cholesterol: Which is most important? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. Fasting diet: Can it improve my heart health? Statin intolerance. Risk factors include: Grapefruit juice contains a chemical that can interfere with the enzymes that break down (metabolize) the statins in your digestive system. Statins work by drawing cholesterol out of the plaque that builds up in the walls of your arteries. European Heart Journal. If you think you're experiencing side effects from statins, don't just stop taking the pills. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins. A strong predictor you'll experience muscle aches when taking statins could be whether or not you read about the potential side effect. However, certain beta blockers — another blood pressure medication — can cause weight gain. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm293330.htm. American Heart Association. Pravastatin needs to be paired with a low-cholesterol and low-fat diet. 2020 Alonso R, et al. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Pravastatin carries the risk of certain side effects such as muscle cramps and myalgia. Here are six tips to help you get started. Potential side effects differ across the different categories of cholesterol drugs, making it important to read all the packaging information carefully and talk to your doctor about potential interactions. Cholesterol: Top foods to improve your numbers, Cholesterol-lowering supplements may be helpful. 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