Gerald M. Borok, Ph.D., is Director, Health Economics and Outcomes Research; Sanjay K. Gandhi, Ph.D., is Director, Health Economics and Outcomes Research; and Kenneth L. Mcdonough, M.D., is Medical Director, Managed Markets, AstraZeneca LP, Wilmington. Administrative claims and medical records were used to assign patients a cardiovascular risk status and corresponding LDL cholesterol goal using guidelines from the National Cholesterol Education Program (NCEP). Please use this form to submit your questions or comments on how to make this article more useful to clinicians. Will Biased Ligands Be the Opioids of the Future? Methods: Electronic medical and pharmacy administrative claims from a western U.S. health plan with approximately 8 million covered members were extracted and used in this retrospective, longitudinal cohort study. Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia. Please check this other discussion --- 2nd URL National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, J-STAGE, Japan Science and Technology Information Aggregator, Electronic. Michael F. Bullano; Siddhesh Kamat; Debra A. Wertz; Gerald M. Borok; Sanjay K. Gandhi; Kenneth L. McDonough; Vincent J. Willey. Propensity-score matching on baseline characteristics was used to minimize selection bias between groups. Patients receiving rosuvastatin were more likely to attain NCEP LDL cholesterol goals compared with patients treated with atorvastatin. However, physicians tended to switch to more intensive therapy for DM in the atorvastatin group. Malays Fam Physician. [3] These guidelines are based on results from previous randomized clinical trials and include specific goals for LDL cholesterol. Crestor comes in the forms of 5, 10, 20 and 40-milligram tablets, and Lipitor comes in the form of 10, 20, 40 and 80-milligram tablets. 2007;64(3):276-284. DCI = Deyo-Charlson comorbidity index; ATP III = Adult Treatment Panel III b p < 0.05 for comparison between drugs. Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. Burnout Might Really Be Depression; How Do Doctors Cope? 2010 Mar;25(1):27-35. doi: 10.3904/kjim.2010.25.1.27. Results: A total of 453 patients met the study criteria. Epub 2009 Oct 16. aCoronary heart disease (CHD) risk equivalent includes myocardial infarction, angioplasty, coronary artery bypass graft, stroke, diabetes, and peripheral vascular disease. © 2007  American Society of Health-System Pharmacists, aATP III = Adult Treatment Panel III. Am J Health Syst Pharm. [5,6,7] In clinical trials, rosuvastatin has produced significantly greater reductions in LDL cholesterol and greater NCEP goal attainment rates than atorvastatin at comparable doses. There were no significant differences between the 2 groups in the effect on non-high-density lipoprotein cholesterol (non-HDL-C) and HbA1c at 12 months. NLM Please enable it to take advantage of the complete set of features!  |  aLDL = low-density-lipoprotein. Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients with concomitant type 2 diabetes. Is Atorvastatin Associated with New Onset Diabetes or Deterioration of Glycemic Control? [17] This may be due to factors usually associated with controlled, clinical trials, such as more frequent lipid monitoring; greater awareness of diet, exercise, clinical team support, and treatment reinforcement resulting from study participation; appropriate dosage adjustments; and increased medication compliance due to the free study drug. d p < 0.05, compared with rosuvastatin. Epub 2019 Aug 19. Changes in lipid levels and attainment rates of goal LDL cholesterol levels were estimated after accounting for baseline covariates using regression techniques. Since LDL cholesterol is the primary target of therapy, ATP III identified three classes of cardiovascular risk (low, moderate, and high) that describe LDL cholesterol levels. BMC Fam Pract. Sunjaya AP, Sunjaya AF, Halim S, Ferdinal F. Int J Angiol. Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. 2010 Jan 1;105(1):69-76. doi: 10.1016/j.amjcard.2009.08.651. Get the latest public health information from CDC: https://www.coronavirus.gov. Clipboard, Search History, and several other advanced features are temporarily unavailable. The mean dose of rosuvastatin was 11 mg compared with 15 mg for atorvastatin. Compare Crestor vs Lipitor head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Please confirm that you would like to log out of Medscape. ClinicalTrials.gov NCT01544309. Lipitor and Crestor are also used to reduce the risk of heart attacks, stroke, and arterial revascularization procedures in patients with multiple risk factors for heart disease. Siddhesh Kamat, M.S., is Outcomes Research Manager; and Debra A. Wertz, Pharm.D., is Senior Clinical Analyst/Medical Writer, Health Outcomes Research, HealthCore. After adjusting for baseline differences between groups, patients receiving rosuvastatin had significantly greater mean percent reductions in LDL cholesterol, total cholesterol, and non-high-density-lipoprotein (non-HDL) cholesterol than did patients receiving atorvastatin (p < 0.001 for all comparisons). no. Lipitor ® (atorvastatin calcium) and Crestor ® (rosuvastatin calcium) are both cholesterol medications. 2009 Dec;36(3):412-8. doi: 10.1007/s12020-009-9235-6. cInsufficient sample size to detect statistically significant differences (power = 39%) in goal attainment across statin groups (p = 0.088). The 1,049 patients were randomly assigned to either the rosuvastatin group or atorvastatin group. eAdjusted for age, sex, baseline laboratory values, duration of therapy, and National Cholesterol Education Program risk status. Since cholesterol synthesis peaks between midnight and 2 am, simvastatin, pravastatin, fluvastatin, and pitavastatin have a shorter half-life and should be taken at bedtime. Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. 2003 Dec 1;4:18. doi: 10.1186/1471-2296-4-18. Epub 2008 Dec 6. 2007;64(3):276-284. aLDL = low-density-lipoprotein, ATP III = Adult Treatment Panel III. In response to results from recent clinical trials, Grundy et al. cDifference between preindex and postindex LDL cholesterol. Since LDL cholesterol goals differed using the ATP III guidelines alone versus in combination with the updated ATP III optional goals, the number of eligible patients in each of these analyses varied. All of these factors are unlikely to represent everyday clinical practice settings. Rosuvastatin 5 mg and atorvastatin 10 mg have a similar lowering effect on non-HDL-C, but might be different in terms of adverse effect on glucose levels. eAdjusted for age, sex, baseline laboratory test values, duration of therapy, and National Cholesterol Education Program risk status. 2017 Jul 5;8(4):383-391. doi: 10.1007/s13340-017-0328-9. [1] Previous epidemiologic studies and clinical trials have consistently shown the clinical benefits associated with reducing low-density-lipoprotein (LDL) cholesterol[2,3,4,5,6,7,8,9,10,11] and total cholesterol. Lipitor (atorvastatin) and Crestor (rosuvastatin) are HMG-CoA reductase inhibitors (“statin” drugs) that lower cholesterol levels in the blood. Purpose: The effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density-lipoprotein (LDL) cholesterol goals in patients treated in a usual care setting was studied. b n denotes number of patients not at goal at baseline. 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