2019, Article ID 3173745, 10 pages, 2019. https://doi.org/10.1155/2019/3173745, 1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia, 2Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt, 3Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. B. Thomson, and T. W. Kelsey, “The radiosensitivity of the human oocyte,”, C. Borek, “Antioxidants and radiation therapy,”, S. L. Fawcett, A. C. Gomez, S. J. Barter, M. Ditchfield, and P. Set, “More harm than good? Epub 2012 Mar 27. Thymol and carvacrol can also be applied as an alternative antimicrobial agent against antibiotic-resistant pathogenic bacteria. The authors declare that they have no conflicts of interest. However, PCNA immunoreactivity was present only in oocytes of primordial follicles with stain-free pregranulosa cells. Therefore, another mechanism by which these compounds enhance the in vivo follicular development could be a result of decreasing irradiation-mediated inflammatory signals. Then, the supernatant was obtained by centrifugation at 10,000 g for 15 minutes and kept at -80°C until the assessment of total antioxidant capacity (TAC) and TNF-α inflammatory marker activity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o provide an accurate assessment of the follicular reserve as related to functional maturation of the ovary, serum AMH was assayed during the prepubertal period using the AMH ELISA Kit (Uscn Life Science Inc., Wuhan). In contrast, CAR and thymol-irradiated rats showed a significant reduction in serum FSH levels as compared with the irradiated group; however, they are still higher than the control group as shown in Figure 2(c). Carvacrol (2-hydroxy-4-cymene; isothymol) and thymol (2-isopropyl-5-methylphenol) were obtained from Extrasynthese Co. (Z.I. On the other hand, irradiated ovaries showed marked shrinkage of the ovary and most of the follicles are degenerated with degenerated oocytes (arrows) as shown in Figure 1(b). The results demonstrate the binding possibility of the natural compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) to the viral main protease (Mpro). 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Daferera et al., “The, A. Sivaranjani, G. Sivagami, and N. Nalini, “Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis,”, M. Kianmehr, A. Rezaei, and M. H. Boskabady, “Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice,”, B. Aristatile, A. H. Al-Assaf, and K. V. Pugalendi, “Carvacrol suppresses the expression of inflammatory marker genes in D-galactosamine-hepatotoxic rats,”, M.-L. Tsai, C.-C. Lin, W.-C. Lin, and C.-H. Yang, “Antimicrobial, antioxidant, and anti-inflammatory activities of essential oils from five selected herbs,”, A. Jafari, Y. Rasmi, M. Hajaghazadeh, and M. Karimipour, “Hepatoprotective effect of thymol against subchronic toxicity of titanium dioxide nanoparticles: biochemical and histological evidences,”, D. Liang, F. Li, Y. Fu et al., “Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-, S. M. Abedi, F. Yarmand, M. Motallebnejad et al., “Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats,”, Y. K. Lee, H. H. Chang, W. R. Kim, J. K. Kim, and Y. D. Yoon, “Effects of gamma-radiation on ovarian follicles,”, B. D. Ozen and M. Uyanoglu, “Effect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver,”, G. Türkcü, U. Alabalık, A. N. Keleş et al., “Protective effects of carvacrol and pomegranate against methotrexate-induced intestinal damage in rats,”, K. Koc, S. Cerig, S. Ucar et al., “Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats,”, K. L. Britt, A. E. Drummond, V. A. Cox et al., “An age-related ovarian phenotype in mice with targeted disruption of the, R. H. Braw and A. Tsafriri, “Effect of PMSG on follicular atresia in the immature rat ovary,”, K. Oktay, R. S. Schenken, and J. F. Nelson, “Proliferating cell nuclear antigen marks the initiation of follicular growth in the rat,”, K. Jankowska, “Premature ovarian failure,”, Y. F. Mahran, E. El-Demerdash, A. S. Nada, R. N. El-Naga, A.

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