Saccharin. If you're at a loss as to what sweeteners are the healthiest option, use the following guide for the worst and best sugar substitutes. However, if you are allergic to sulfa drugs, saccharin can cause itching and hives when ingested. Saccharin, the sweetening agent in Sweet’N Low, offers 300 times the sweetness of table sugar. Whether you use regular sugar, no sugar, or sugar substitutes, it’s always nice to save a little money. There has always been a lot of debate around sugar substitutes, but I do know they are popular. Find Sweet and Low Coupons Here: $.50 Off Sweet n Low Coupons Printable. Sugar Substitution. The U.S. Food and Drug Administration has approved five artificial sweeteners: saccharin (Sweet’N Low, Sweet Twin), acesulfame (Sweet One, Sunett), … Once linked with the development of bladder cancer in rats, saccharin is not a human carcinogen, explains the National Cancer Institute 1. In recipes for sweetened sauces and beverages, all the sugar can be replaced with Sweet'N Low. Artificial sweeteners are many times sweeter than sugar, so it takes a smaller amount to sweeten foods. Saccharin (Sweet'N Low) Aspartame (NutraSweet, Equal) Acesulfame potassium (Sunett) Sucralose (Splenda) Stevia (Pure Via, Truvia) Artificial sweeteners, also called sugar substitutes, low-calorie sweeteners or nonnutritive sweeteners, offer the sweetness of sugar without the calories. Sweet'N Low Granulated Sugar Substitute, 250 Count, Pack of 8 by Sweet 'N Low. 4.7 out of 5 stars 2 ratings. If you’re diabetic or simply watching your intake of sugar, here are the most common sugar replacements as well as how much of the product to use to achieve the correct level of sweetness in your favorite recipes. This happens when we fast for prolonged periods, like overnight. 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